Chlorogenic acid permeation across intestinal cell monolayers: Influence by circadian rhythms in the presence of other natural polyphenols and by dopaminergic neuronal-like cells

Chlorogenic acid permeation across intestinal cell monolayers: Influence by circadian rhythms in the presence of other natural polyphenols and by dopaminergic neuronal-like cells

Blog Article

Poor oral bioavailability limits chlorogenic acid (CGA) benefits on the gut-brain axis.In Trucker Caps this study we demonstrate the existence of an active circadian-dependent efflux for the CGA intestinal permeation, leading to greater bioavailability in the evening rather than in the morning.As therapeutic/nutraceutical polyphenols can mutually influence their intestinal absorption following circadian rhythms, we also evaluated the effects of other polyphenols on CGA permeation/bioavailability.The results indicate that gallic acid reduced in vitro CGA permeation across IEC-6 cell monolayers, as well as rat oral CGA bioavailability.

On the contrary, arbutin, caffeic acid and ferulic acid did not modify in vitro CGA permeation.Finally, 60 mM KCl-evoked Crochet Kits dopamine release from PC12 cells significantly increased intestinal CGA permeation, likely by downregulating the expression/activity of efflux transporters, as confirmed by western blot analysis.Dopamine released from the enteric nervous system may therefore increase the dependence of oral bioavailability of CGA on circadian rhythms.